A novel isoform of the orphan nuclear receptor ROR β is specifically expressed in pineal gland and retina
Identifieur interne : 000C45 ( Main/Exploration ); précédent : 000C44; suivant : 000C46A novel isoform of the orphan nuclear receptor ROR β is specifically expressed in pineal gland and retina
Auteurs : Elisabeth André [Suisse] ; Katrin Gawlas [Pays-Bas] ; Markus Steinmayr [Allemagne] ; Michael Becker-André [Suisse]Source :
- Gene [ 0378-1119 ] ; 1998.
Abstract
RORβ is a member of the nuclear hormone receptor superfamily whose ligand is unknown. Expression of RORβ is confined to the central nervous system and its pattern suggests that this orphan nuclear receptor is implicated in the processing of sensory information and in circadian timing. In rats, RORβ mRNA levels oscillate robustly in pineal gland and retina, displaying a 24h rhythm. Here we report the cloning of the cDNA of a novel isoform of RORβ from rat pineal tissue. Expression of this isoform, called RORβ2, is confined to pineal gland and retina and strongly increases at night. RORβ2 shares common DNA- and putative ligand-binding domains with the canonical RORβ (referred to as RORβ1), but is characterized by a different amino-terminal domain. This structural difference renders RORβ2 much more selectively binding to DNA than RORβ1. Moreover, in contrast to RORβ1, the novel isoform efficiently activates transcription also in non-neuronal cell lines. Thus, the two RORβ isoforms are likely to regulate different sets of genes in different physiological contexts.
Url:
DOI: 10.1016/S0378-1119(98)00348-5
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>A novel isoform of the orphan nuclear receptor ROR β is specifically expressed in pineal gland and retina</title><author><name sortKey="Andre, Elisabeth" sort="Andre, Elisabeth" uniqKey="Andre E" first="Elisabeth" last="André">Elisabeth André</name></author><author><name sortKey="Gawlas, Katrin" sort="Gawlas, Katrin" uniqKey="Gawlas K" first="Katrin" last="Gawlas">Katrin Gawlas</name></author><author><name sortKey="Steinmayr, Markus" sort="Steinmayr, Markus" uniqKey="Steinmayr M" first="Markus" last="Steinmayr">Markus Steinmayr</name></author><author><name sortKey="Becker Andre, Michael" sort="Becker Andre, Michael" uniqKey="Becker Andre M" first="Michael" last="Becker-André">Michael Becker-André</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A22D25BEBAE94025B2269BAB785D496C150DD876</idno><date when="1998" year="1998">1998</date><idno type="doi">10.1016/S0378-1119(98)00348-5</idno><idno type="url">https://api.istex.fr/document/A22D25BEBAE94025B2269BAB785D496C150DD876/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000538</idno><idno type="wicri:Area/Main/Curation">000535</idno><idno type="wicri:Area/Main/Exploration">000C45</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Exploration">000C45</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A novel isoform of the orphan nuclear receptor ROR β is specifically expressed in pineal gland and retina</title><author><name sortKey="Andre, Elisabeth" sort="Andre, Elisabeth" uniqKey="Andre E" first="Elisabeth" last="André">Elisabeth André</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Serono Pharmaceutical Research Institute S.A., 14, chemin des Aulx, CH-1228 Plan-les-Ouates</wicri:regionArea><wicri:noRegion>CH-1228 Plan-les-Ouates</wicri:noRegion></affiliation></author><author><name sortKey="Gawlas, Katrin" sort="Gawlas, Katrin" uniqKey="Gawlas K" first="Katrin" last="Gawlas">Katrin Gawlas</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>University of Nijmegen, Toernooiveld 1, NL-6525 ED Neijmegen</wicri:regionArea><wicri:noRegion>NL-6525 ED Neijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Steinmayr, Markus" sort="Steinmayr, Markus" uniqKey="Steinmayr M" first="Markus" last="Steinmayr">Markus Steinmayr</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Schering AG, Heinrich Heine Str. 20, D-10179 Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Becker Andre, Michael" sort="Becker Andre, Michael" uniqKey="Becker Andre M" first="Michael" last="Becker-André">Michael Becker-André</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Serono Pharmaceutical Research Institute S.A., 14, chemin des Aulx, CH-1228 Plan-les-Ouates</wicri:regionArea><wicri:noRegion>CH-1228 Plan-les-Ouates</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Gene</title><title level="j" type="abbrev">GENE</title><idno type="ISSN">0378-1119</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">216</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="277">277</biblScope><biblScope unit="page" to="283">283</biblScope></imprint><idno type="ISSN">0378-1119</idno></series><idno type="istex">A22D25BEBAE94025B2269BAB785D496C150DD876</idno><idno type="DOI">10.1016/S0378-1119(98)00348-5</idno><idno type="PII">S0378-1119(98)00348-5</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-1119</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">RORβ is a member of the nuclear hormone receptor superfamily whose ligand is unknown. Expression of RORβ is confined to the central nervous system and its pattern suggests that this orphan nuclear receptor is implicated in the processing of sensory information and in circadian timing. In rats, RORβ mRNA levels oscillate robustly in pineal gland and retina, displaying a 24h rhythm. Here we report the cloning of the cDNA of a novel isoform of RORβ from rat pineal tissue. Expression of this isoform, called RORβ2, is confined to pineal gland and retina and strongly increases at night. RORβ2 shares common DNA- and putative ligand-binding domains with the canonical RORβ (referred to as RORβ1), but is characterized by a different amino-terminal domain. This structural difference renders RORβ2 much more selectively binding to DNA than RORβ1. Moreover, in contrast to RORβ1, the novel isoform efficiently activates transcription also in non-neuronal cell lines. Thus, the two RORβ isoforms are likely to regulate different sets of genes in different physiological contexts.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Pays-Bas</li><li>Suisse</li></country><region><li>Berlin</li></region><settlement><li>Berlin</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Andre, Elisabeth" sort="Andre, Elisabeth" uniqKey="Andre E" first="Elisabeth" last="André">Elisabeth André</name></noRegion><name sortKey="Becker Andre, Michael" sort="Becker Andre, Michael" uniqKey="Becker Andre M" first="Michael" last="Becker-André">Michael Becker-André</name></country><country name="Pays-Bas"><noRegion><name sortKey="Gawlas, Katrin" sort="Gawlas, Katrin" uniqKey="Gawlas K" first="Katrin" last="Gawlas">Katrin Gawlas</name></noRegion></country><country name="Allemagne"><region name="Berlin"><name sortKey="Steinmayr, Markus" sort="Steinmayr, Markus" uniqKey="Steinmayr M" first="Markus" last="Steinmayr">Markus Steinmayr</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C45 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000C45 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Musique
|area= SchutzV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A22D25BEBAE94025B2269BAB785D496C150DD876
|texte= A novel isoform of the orphan nuclear receptor ROR β is specifically expressed in pineal gland and retina
}}
| This area was generated with Dilib version V0.6.38. |  |